D089 | Myc inhibitor | Probechem Biochemicals

Chemical Structure : D089

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D089 (D 089)

货号: PC-47053Not For Human Use, Lab Use Only.

D089 is a selective small molecule stabilizer of the MYC G4-quadruplex, not only inhibits MYC expression in myeloma cell lines, but also selectively induces G1 arrest in MYC-driven cancer cell lines containing the MYC-G4 sequence.

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生物&药学活性

D089 is a selective small molecule stabilizer of the MYC G4-quadruplex, not only inhibits MYC expression in myeloma cell lines, but also selectively induces G1 arrest in MYC-driven cancer cell lines containing the MYC-G4 sequence.
D089 reduces MYC transcription and induces cytotoxicity in myeloma cells (L363 MM cells, IC50=13 uM).
D089 induces the canonical pathways involved in the unfolded protein response, endoplasmic reticulum stress, and inflammatory responses to modulate cell cycle progression, senescence and caspase 1-mediated cell death by pyroptosis.
D089 kills cells independent of effector caspase 3 (CASP3), induces caspase-1 and 8 dependent cell death mechanism (pyroptosis).

物理化学性质&存储条件

分子量	392.499
分子式	C24H28N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(azepan-1-ylmethyl)-5-hydroxy-2-methyl-N-(p-tolyl)benzofuran-3-carboxamide

参考文献

1. Snehal M Gaikwad, et al. Cancers (Basel). 2020 Oct 13;12(10):2952.

D089 (D 089)

生物&药学活性

物理化学性质&存储条件

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D089 (D 089)

生物&药学活性

物理化学性质&存储条件

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