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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-IRE1-D-F07
D-F07

Chemical Structure : D-F07

CAS No.: 2361297-58-5

D-F07

货号: PC-47077Not For Human Use, Lab Use Only.

D-F07 is a novel fluorescent, covalent IRE-1 inhibitor, potently inhibits XBP-1s expression in MM cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    D-F07 is a novel fluorescent, covalent IRE-1 inhibitor, potently inhibits XBP-1s expression in MM cells.
    D-F07 suppressed the expression of XBP-1s in both human and mouse myeloma cells in a dose-dependent manner.

    物理化学性质&存储条件

    分子量 347.367
    分子式 C18H21NO6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    7-(1,3-dioxan-2-yl)-8-hydroxy-9-methoxy-3-methyl-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one

    参考文献

    1. Andong Shao, et al. J Med Chem. 2019 Jun 13;62(11):5404-5413.

    2. Andong Shao, et al. Mol Cancer Ther. 2020 Dec;19(12):2432-2444.

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