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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HBV-D-CAM-14
D-CAM-14

Chemical Structure : D-CAM-14

CAS No.:

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D-CAM-14

货号: PC-25703Not For Human Use, Lab Use Only.

D-CAM-14 is a potent, dimeric HBV capsid assembly modulator (CAM) with anti-HBV activity EC50/EC90 of 0.1/9 nM in HepAD38 cells, reduces HBeAg and HBcAg with IC50 of 98 and 67 nM in HBV-Infected HepG2-NTCP cells respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

D-CAM-14 is a potent, dimeric HBV capsid assembly modulator (CAM) with anti-HBV activity EC50/EC90 of 0.1/9 nM in HepAD38 cells, reduces HBeAg and HBcAg with IC50 of 98 and 67 nM in HBV-Infected HepG2-NTCP cells respectively.

物理化学性质&存储条件

分子量 1027.14
分子式 C52H62F4N12O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3,4-difluorophenyl)-4-(2-(((1-(14-(4-((2-(4-((3,4-difluorophenyl)carbamoyl)-1,3,5-trimethyl-1H-pyrrol-2-yl)-2-oxoacetamido)methyl)-1H-1,2,3-triazol-1-yl)tetradecyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-2-oxoacetyl)-1,3,5-trimethyl-1H-pyrrole-2-carboxamide

参考文献

1. Amblard F, et al. J Med Chem. 2025 Nov 6. doi: 10.1021/acs.jmedchem.5c01983.

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