D-AP5 | NMDAR antagonist | Probechem Biochemicals

Chemical Structure : D-AP5

CAS No.: 79055-68-8

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D-AP5 (D-APV, D-2-Amino-5-phosphonovaleric acid)

货号: PC-38029Not For Human Use, Lab Use Only.

D-AP5 is a selective NMDA receptor antagonist that competes with glutamate binding with Kd of 1.4 uM, is commonly used to inhibit NMDA-dependent synaptic plasticity.

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10 mg	￥1280	In stock
25 mg	￥2280	In stock
50 mg	￥3880	In stock
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生物&药学活性

D-AP5 is a selective NMDA receptor antagonist that competes with glutamate binding with Kd of 1.4 uM, is commonly used to inhibit NMDA-dependent synaptic plasticity.
D-AP5 reduces NMDA-induced depolarization of cortical neurons in vitro.
Following spinal injection, D-AP5 results in rapid reduction of NMDA-response but no effect on spontaneously active neurons.

物理化学性质&存储条件

分子量	197.127
分子式	C5H12NO5P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-Amino-5-phosphonopentanoic acid

参考文献

1. Davies J, et al. Brain Res. 1986 Sep 10;382(1):169-73.

2. Javitt DC, et al. Neurosci Lett. 1987 Jul 22;78(2):193-8.

3. Manallack DT, et al. Neuroscience. 1989;30(1):87-94.

4. Coleman PA, et al. J Neurosci. 1988 Dec;8(12):4728-33.

D-AP5 (D-APV, D-2-Amino-5-phosphonovaleric acid)

生物&药学活性

物理化学性质&存储条件

参考文献

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D-AP5 (D-APV, D-2-Amino-5-phosphonovaleric acid)

生物&药学活性

物理化学性质&存储条件

参考文献

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