D-520 |CAS:1619269-47-4 Probechem Biochemicals

Chemical Structure : D-520

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D-520 (D520)

货号: PC-35490Not For Human Use, Lab Use Only.

D-520 is a potent, multifunctional D2/D3 agonist with Ki of 41.8 /0.35 nM, modulates aggregation of alpha-synuclein (αSN) and reduces toxicity of preformed aggregates of αSN.

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生物&药学活性

D-520 is a potent, multifunctional D2/D3 agonist with Ki of 41.8 /0.35 nM, modulates aggregation of alpha-synuclein (αSN) and reduces toxicity of preformed aggregates of αSN.
D-520 clearly demonstrates the effect of neuroprotection from toxicity of 6-hydroxydopamine, produces efficacious activity in the animal models for PD.

物理化学性质&存储条件

分子量	501.671
分子式	C31H39N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4'-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)biphenyl-3,4-diol

参考文献

1. Modi G, et al. ACS Chem Neurosci. 2014 Aug 20;5(8):700-17.

2. Singh SK, et al. Future Med Chem. 2017 Jun;9(10):1039-1053.

3. Yedlapudi D, et al. Sci Rep. 2016 Dec 5;6:38510.

D-520 (D520)

生物&药学活性

物理化学性质&存储条件

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D-520 (D520)

生物&药学活性

物理化学性质&存储条件

参考文献

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