Cyy-272 | JNK inhibitor | Probechem Biochemicals

Chemical Structure : Cyy-272

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Cyy-272 (Cyy272)

货号: PC-28711Not For Human Use, Lab Use Only.

Cyy-272 is an orally active JNK inhibitor with IC50 of 1.25 μM, 1.07 μM and 1.24 μM for JNK1, JNK2 and JNK3, attenuates LPS-stimulated Acute lung injury (ALI), exhibits anti-inflammation activity by inhibiting JNK phosphorylation.

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生物&药学活性

Cyy-272 is an orally active JNK inhibitor with IC50 of 1.25 μM, 1.07 μM and 1.24 μM for JNK1, JNK2 and JNK3, attenuates LPS-stimulated Acute lung injury (ALI), exhibits anti-inflammation activity by inhibiting JNK phosphorylation.
Cyy-272 inhibits the inflammatory cytokine expression in MPMs, decreases the overexpression of TNF-α, IL-6 and IL-1β mRNA in LPS-challenged MPMs.
Cyy-272 inhibits the inflammatory cytokine expression in ALI mice.
Cyy-272 alleviates LPS-induced ALI in vivo.
Cyy-272 exerts anti-inflammatory effects by specifically inhibiting LPS-induced JNK phosphorylation in RAW 264.7.

物理化学性质&存储条件

分子量	435.48
分子式	C23H23F2N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-(4-(4,4-Difluoropiperidin-1-yl)phenyl)-N4-(1H-indazol-6-yl)-5-methylpyrimidine-2,4-diamine

参考文献

1. Liu Q, et al. Toxicol Appl Pharmacol. 2021 Oct 1;428:115648.

2. Liu X, et al. Biomed Pharmacother. 2024 Sep;178:117172.

Cyy-272 (Cyy272)

生物&药学活性

物理化学性质&存储条件

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Cyy-272 (Cyy272)

生物&药学活性

物理化学性质&存储条件

参考文献

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