Cysmethynil | ICMT inhibitor | Probechem Biochemicals

Chemical Structure : Cysmethynil

CAS No.: 851636-83-4

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Cysmethynil (ICMT inhibitor)

货号: PC-70250Not For Human Use, Lab Use Only.

Cysmethynil is a selective small-molecule inhibitor of tisoprenylcysteine carboxyl methyltransferase (Icmt) with IC50 <200 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
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100 mg		Get quote

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生物&药学活性

Cysmethynil is a selective small-molecule inhibitor of tisoprenylcysteine carboxyl methyltransferase (Icmt) with IC50 <200 nM.
Cysmethynil does not inhibit other enzymes (farensyltransferase, geranylgeranyltransferase type I, and Rce1) at concentrations up to 50 uM.
Cysmethynil acts as a competitive inhibitor with respect to the isoprenylated cysteine substrate and a noncompetitive inhibitor with respect to S-adenosylmethionine (Ki=0.14 uM).
Cysmethynil causes decrease in Ras carboxylmethylation, mislocalization of Ras, and impaired signaling through Ras pathways, reduces mTOR signaling and results in both an accumulation of cells in the G(1) phase and cell death in PC3 cells.

物理化学性质&存储条件

分子量	376.5
分子式	C25H32N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-Methylphenyl)-1-octyl-1H-indole-3-acetamide

参考文献

1. Winter-Vann AM, et al. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4336-41.

2. Baron RA, et al. Biochemistry. 2007 Jan 16;46(2):554-60.

3. Wang M, et al. J Biol Chem. 2008 Jul 4;283(27):18678-84.

Cysmethynil (ICMT inhibitor)

生物&药学活性

物理化学性质&存储条件

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Cysmethynil (ICMT inhibitor)

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物理化学性质&存储条件

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