Cypin inhibitor B9

Chemical Structure : Cypin inhibitor B9

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货号: PC-21742Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Cypin inhibitor B9 is a small molecule cypin (cytosolic postsynaptic density protein 95 interactor) inhibitor, attenuates SCI-induced neuropathic pain, potentially by interfering with uric acid (UA) production.
B9 alleviates mechanical pain but does not affect locomotor function.
B9 does not exacerbate lesion volume at the epicenter.
B9 does not aggravate glutamate-induced excitotoxic death of SC neurons in vitro.
B9 reduces mechanical pain without exerting major detrimental effects following SCI.
Cypin is the primary guanine deaminase (GDA) in the central nervous system (CNS), promoting the metabolism of guanine to xanthine, an important reaction in the purine salvage pathway.

物理化学性质&存储条件

分子量	351.83
分子式	C20H18ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(4-chlorophenyl)piperazin-1-yl)(quinolin-2-yl)methanone

参考文献

1. Nisha K Singh, et al. eNeuro. 2024 Feb 1:ENEURO.0451-23.2024.