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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-Cyclosporin A
Cyclosporin A

Chemical Structure : Cyclosporin A

CAS No.: 59865-13-3

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Cyclosporin A (Cyclosporine A, CsA)

货号: PC-22839Not For Human Use, Lab Use Only.

Cyclosporin A (CsA, Cyclosporine A) is a immunosuppressant agent and highly specific inhibitor of the Ca2+/calmodulin-dependent protein phosphatase PP2B with IC50 of 65 nM in rat pancreatic acinar cells.

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100 mg ￥480 In stock
500 mg ￥980 In stock
1 g ￥1480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cyclosporin A (CsA, Cyclosporine A) is a immunosuppressant agent and highly specific inhibitor of the Ca2+/calmodulin-dependent protein phosphatase PP2B with IC50 of 65 nM in rat pancreatic acinar cells.
Cyclosporin A also inhibits cholecystokinin-, 100 pM, or carbamylcholine-, 10 microM, induced amylase release in a concentration-dependent manner.
Cyclosporin A specifically blocks the cholecystokinin-stimulated dephosphorylation of a 24-kDa protein in a concentration range similar to that seen for inhibition of secretion.
Cyclosporin A stimulates glucose-induced insulin secretion by inhibiting the activity of PP2B, an event that may be involved in mechanisms governing glucose-induced insulin secretion via dephosphorylation of synapsin I-like protein in MIN6 cells.

物理化学性质&存储条件

分子量 1202.64
分子式 C62H111N11O12
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

参考文献

1. Groblewski GE, et al. J Biol Chem. 1994 May 27;269(21):15111-7.

2. Yoshida T, et al. J Cell Sci. 1994 Jul;107 ( Pt 7):1725-35.

3. Ebihara K, et al. Endocrinology. 1996 Dec;137(12):5255-63.

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