Cyclopamine | hedgehog | Probechem Biochemicals

Chemical Structure : Cyclopamine

CAS No.: 4449-51-8

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Cyclopamine (11-Deoxojervine)

货号: PC-45147Not For Human Use, Lab Use Only.

Cyclopamine is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Cyclopamine is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM.
Cyclopamine inhibits hedgehog-dependent expression of Pax7 with IC50 of 24 nM, blocks the response of neural plate explants to recombinant Shh-N; A useful tool in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.

物理化学性质&存储条件

分子量	411.6199
分子式	C27H41NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 0.32 mg/mL (Need ultrasonic)
Chemical Name/SMILES	Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-

参考文献

1. Peukert S, et al. Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31.

2. Cooper MK, et al. Science. 1998 Jun 5;280(5369):1603-7.

3. Incardona JP, et al. Development. 1998 Sep;125(18):3553-62.

Cyclopamine (11-Deoxojervine)

生物&药学活性

物理化学性质&存储条件

参考文献

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Cyclopamine (11-Deoxojervine)

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物理化学性质&存储条件

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