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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA/RNA Synthesis-Cycloheximide
Cycloheximide

Chemical Structure : Cycloheximide

CAS No.: 66-81-9

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Cycloheximide (Naramycin A, Actidione)

货号: PC-42973Not For Human Use, Lab Use Only.

Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor that inhibits protein biosynthesis in eukaryotic organisms with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively.

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250 mg ￥880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor that inhibits protein biosynthesis in eukaryotic organisms with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively.
Cycloheximide blocks the elongation phase of eukaryotic translation, binds the ribosome and inhibits eEF2-mediated translocation.
Cycloheximide impairs memory more as footshock intensity increases, enhances memory in an inverted-U dose-response manner at low dose.
Cycloheximide also sensitizes COLO 205 cells to TNF-alpha-induced programmed cell death.

物理化学性质&存储条件

分子量 281.3474
分子式 C15H23NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: >33 mg/mL; H2O: 20 mg/mL (Need ultrasonic and warming)

Chemical Name/SMILES

2,6-Piperidinedione, 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-

参考文献

1. Schneider-Poetsch T, et al. Nat Chem Biol. 2010 Mar;6(3):209-217.

2. Gold PE, et al. Behav Brain Res. 2012 Aug 1;233(2):293-7.

3. Neeman M, et al. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5585-9.

4. Pajak B, et al. J Physiol Pharmacol. 2005 Jun;56 Suppl 3:101-18.

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