Cyanorona-20 | SARS-CoV-2 inhibitor | Probechem Biochemicals

Chemical Structure : Cyanorona-20

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Cyanorona-20 (Cyanorona 20)

货号: PC-72126Not For Human Use, Lab Use Only.

Cyanorona-20 is a potent and specific SARS-CoV-2 inhibitor with very high selectivity (209- and 45-fold more potent than favipiravir and remdesivir, respectively), effectively binds to and inhibits the SARS-CoV-2 RdRp.

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生物&药学活性

Cyanorona-20 is a potent and specific SARS-CoV-2 inhibitor with very high selectivity (209- and 45-fold more potent than favipiravir and remdesivir, respectively), effectively binds to and inhibits the SARS-CoV-2 RdRp.
Cyanorona-20 exhibited very significant anti-COVID-19 activity (anti-SARS-CoV-2 viral redcution EC50=0.45 uM, CPE IC100=1.4 uM, 50% reduction in viral RNA EC50=0.48 uM), SARS-CoV-2 in vitro.
Cyanorona-20 strongly binds with the pivotal amino acid residue of the SARS-CoV-2 RdRp active site, Asp760.

物理化学性质&存储条件

分子量	270.223
分子式	C13H7FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[N(E)]-N-[(4-Cyanophenyl)methylene]-6-fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide

参考文献

1. Rabie AM. Chem Zvesti. 2021 May 16:1-17.

2. Rabie AM. Int Immunopharmacol. 2021 Sep;98:107831.

Cyanorona-20 (Cyanorona 20)

生物&药学活性

物理化学性质&存储条件

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Cyanorona-20 (Cyanorona 20)

生物&药学活性

物理化学性质&存储条件

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