Cryptotanshinone | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : Cryptotanshinone

CAS No.: 35825-57-1

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Cryptotanshinone (CP1, Cryptotanshinon, Tanshinone c)

货号: PC-26930Not For Human Use, Lab Use Only.

规格	价格	库存
25 mg	￥480	In stock
50 mg	￥780	In stock
100 mg	￥1180	In stock
250 mg		Get quote

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生物&药学活性

Cryptotanshinone (CP1, Cryptotanshinon) is a potent STAT3 inhibitor with IC50 of 4.6 uM, inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells through blocking the dimerization of STAT3.
Cryptotanshinone binds to the SH2 domain of STAT3.
Cryptotanshinone binds to STAT3 monomer and inhibits the dimerization of STAT3.
Cryptotanshinone sensitively inhibits prostate cancer cells harboring constitutively activated STAT3.
Cryptotanshinone selectively suppresses STAT3 Tyr705 phosphorylation but not through inhibition of upstream tyrosine kinases.
Cryptotanshinone down-regulates the expression of cyclin D1, Bcl-xL, and survivin, and causes the accumulation of cells in G0-G1.

物理化学性质&存储条件

分子量	296.37
分子式	C19H20O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione

参考文献

1. Shin DS, et al. Cancer Res. 2009 Jan 1;69(1):193-202.

2. Lu L, et al. Mol Cell Biochem. 2013 Sep;381(1-2):273-82.

Cryptotanshinone (CP1, Cryptotanshinon, Tanshinone c)

生物&药学活性

物理化学性质&存储条件

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Cryptotanshinone (CP1, Cryptotanshinon, Tanshinone c)

生物&药学活性

物理化学性质&存储条件

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