Crisdesalazine (AAD-2004) | mPGES-1 inhibitor | Probechem Biochemicals

Chemical Structure : Crisdesalazine

CAS No.: 927685-43-6

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Crisdesalazine (AAD-2004, AAD2004)

货号: PC-36090Not For Human Use, Lab Use Only.

Crisdesalazine (AAD-2004, AAD2004) is a derivative of aspirin that inhibits microsomal PGE(2) synthase-1 (mPGES-1) activity in response to both LPS-treated BV2 cell with IC50 of 230 nM and recombinant human mPGES-1 protein with IC50 of 249 nM in vitro.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

Crisdesalazine (AAD-2004, AAD2004) is a derivative of aspirin that inhibits microsomal PGE(2) synthase-1 (mPGES-1) activity in response to both LPS-treated BV2 cell with IC50 of 230 nM and recombinant human mPGES-1 protein with IC50 of 249 nM in vitro.
Crisdesalazin blocked free radical production, PGE(2) formation, and microglial activation in the spinal cords in superoxide dismutase 1(G93A) transgenic mouse model of ALS.
Crisdesalazin reduced autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and increasing life span, which is superior to riluzole or ibuprofen.

物理化学性质&存储条件

分子量	325.287
分子式	C16H14F3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-hydroxy-5-({2-[4-(trifluoromethyl)phenyl]ethyl}amino)benzoic acid

参考文献

1. Shin JH, et al. J Neurochem. 2012 Sep;122(5):952-61.

2. Baek IS, et al. Exp Neurobiol. 2013 Mar;22(1):31-7.

Crisdesalazine (AAD-2004, AAD2004)

生物&药学活性

物理化学性质&存储条件

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Crisdesalazine (AAD-2004, AAD2004)

生物&药学活性

物理化学性质&存储条件

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