Crisaborole (AN-2728) | PDE4 inhibitor | Probechem Biochemicals

Chemical Structure : Crisaborole

CAS No.: 906673-24-3

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Crisaborole (AN-2728, AN2728)

货号: PC-42760Not For Human Use, Lab Use Only.

Crisaborole (AN-2728) is a potent PDE4 inhibitor with IC50 of 0.49 uM.

规格	价格	库存
50 mg	￥580	In stock
100 mg	￥880	In stock
500 mg	￥1980	In stock
1 g		Get quote

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生物&药学活性

Crisaborole (AN-2728) is a potent PDE4 inhibitor with IC50 of 0.49 uM.
Crisaborole (AN-2728) also shows inhibition against PDE1A3, PDE3Cat, and PDE7A1.
Crisaborole (AN-2728) suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.

物理化学性质&存储条件

分子量	251.0451
分子式	C14H10BNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	Benzonitrile, 4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-

参考文献

1. Akama T, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32.

2. Nazarian R, et al. Curr Opin Investig Drugs. 2009 Nov;10(11):1236-42.

3. Freund YR, et al. FEBS Lett. 2012 Sep 21;586(19):3410-4.

Crisaborole (AN-2728, AN2728)

生物&药学活性

物理化学性质&存储条件

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Crisaborole (AN-2728, AN2728)

生物&药学活性

物理化学性质&存储条件

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