欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Cresomycin
Cresomycin

Chemical Structure : Cresomycin

CAS No.: 2999743-51-8

加入收藏

Cresomycin (CRM)

货号: PC-21855Not For Human Use, Lab Use Only.

Cresomycin (CRM) is a bridged macrobicyclic antibiotic via inhibiting bacterial ribosome, shows broad efficacy of CRM against clinical isolates of MDR Gram-negative pathogens differentiates the synthetic macrobicyclic class from traditional lincosamides.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
200 mg Get quote
1 g Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Cresomycin (CRM) is a bridged macrobicyclic antibiotic via inhibiting bacterial ribosome, shows broad efficacy of CRM against clinical isolates of MDR Gram-negative pathogens differentiates the synthetic macrobicyclic class from traditional lincosamides.
Cresomycin (CRM) is broadly superior to Iboxamycin (IBX) in inhibiting the growth of staphylococci (MIC90= 2 versus 8 ug/ml), streptococci MIC90 ≤ 0.06 versus 0.25 μg/ml), enterococci (MIC90 = 0.25 versus 2 μg/m), and Clostridioides difficile (MIC90= 0.125 versus 16 ug/ml).
Cresomycin (CRM) (25 mg/kg, q.i.d., i.p.) reduces the bacterial burden of cfr-expressing S. aureus, ermA-expressing S. aureus (AR-0693), carbapenem-resistant E. coli (AR-0137), and carbapenem-resistant P. aeruginosa (AR-0236) by -4.6, -2.2, -2.6, and -2.7 log10 CFUs, respectively.
Cresomycin (CRM) displaced 50% of bound radiolabeled erythromycin from immobilized E. coli ribosomes IC50 of ≤8.2 nM.
Cresomycin (CRM) exhibits in vitro and in vivo efficacy against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.

物理化学性质&存储条件

分子量 498.68
分子式 C25H42N2O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4S,5aS,8S,8aR)-4-isobutyl-N-((1R,7R,8R,9R,10R,11S,12R,Z)-10,11,12-trihydroxy-7-methyl-13-oxa-2-thiabicyclo[7.3.1]tridec-5-en-8-yl)octahydro-2H-oxepino[2,3-c]pyrrole-8-carboxamide

参考文献

1. Kelvin J Y Wu, et al. Science. 2024 Feb 16;383(6684):721-726.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: