Crenolanib (CP-868596) | PDGFR/FLT-3 inhibitor | Probechem Biochemicals

Chemical Structure : Crenolanib

CAS No.: 670220-88-9

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Crenolanib (CP-868596, CP868596)

货号: PC-43403Not For Human Use, Lab Use Only.

Crenolanib (CP-868596) is a potent, selective PDGFR/Flt-3 inhibitor with Ki of 3.2, 2.1 and 0.74 nM for wild-type PDGFRα, PDGFRβ and FLT3, respectively.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Crenolanib (CP-868596) is a potent, selective PDGFR/Flt-3 inhibitor with Ki of 3.2, 2.1 and 0.74 nM for wild-type PDGFRα, PDGFRβ and FLT3, respectively.
Crenolanib (CP-868596) displays >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.
Crenolanib (CP-868596) also is a potent inhibitor of PDGFRα D842V-mutant kinase with IC50 of 10 nM, significantly more potent than imatinib in inhibiting the kinase activity of imatinib-resistant PDGFRA kinases (D842I, D842V, D842Y, DI842-843IM, and deletion I843).
Crenolanib is active against models of drug-resistant FLT3-ITD-positive AML.

物理化学性质&存储条件

分子量	443.5408
分子式	C26H29N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Piperidinamine, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-

参考文献

1. Heinrich MC, et al. Clin Cancer Res. 2012 Aug 15;18(16):4375-84.

2. Zimmerman EI, et al. Blood. 2013 Nov 21;122(22):3607-15.

3. Galanis A, et al. Blood. 2014 Jan 2;123(1):94-100.

4. Smith CC, et al. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5319-24.

Crenolanib (CP-868596, CP868596)

生物&药学活性

物理化学性质&存储条件

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Crenolanib (CP-868596, CP868596)

生物&药学活性

物理化学性质&存储条件

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