Crebinostat |CAS:1092061-61-4 Probechem Biochemicals

Chemical Structure : Crebinostat

CAS No.: 1092061-61-4

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Crebinostat

货号: PC-62704Not For Human Use, Lab Use Only.

Crebinostat is a novel cognitive enhancer that inhibits class I HDAC/1/2/3 (IC50=0.7/1.0/2.0 nM), class IIb HDAC6 (IC50=9.3 nM) with weaker inhibition of the class I HDAC8 and no significant inhibition of the class IIa HDAC/4/5/7/9.

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生物&药学活性

Crebinostat is a novel cognitive enhancer that inhibits class I HDAC/1/2/3 (IC50=0.7/1.0/2.0 nM), class IIb HDAC6 (IC50=9.3 nM) with weaker inhibition of the class I HDAC8 and no significant inhibition of the class IIa HDAC/4/5/7/9.
Crebinostat potently induces acetylation of both histone H3 and histone H4 as well as enhanced the expression of the CREB target gene Egr1 in cultured mouse primary neurons.
Crebinostat upregulates Bdnf and Grn, and downregulates Mapt (tau) gene expression-genes; brain penetrant.

物理化学性质&存储条件

分子量	353.422
分子式	C20H23N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Heptanoic acid,7-(hydroxyamino)-7-oxo-,2-([1,1'-biphenyl]-4-ylmethylene)hydrazide

参考文献

1. Fass DM, et al. Neuropharmacology. 2013 Jan;64:81-96.

2. Ghosh B, et al. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1265-71.

Crebinostat

生物&药学活性

物理化学性质&存储条件

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Crebinostat

生物&药学活性

物理化学性质&存储条件

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