Cowanin |CAS:21044-85-9 Probechem Biochemicals

Chemical Structure : Cowanin

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Cowanin (NSC 752810)

货号: PC-63246Not For Human Use, Lab Use Only.

Cowanin is a novel natural product from Garcinia speciosa that inhibits the Notch signaling pathway with IC50 of 2.4 uM.

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1 g		Get quote

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生物&药学活性

Cowanin is a novel natural product from Garcinia speciosa that inhibits the Notch signaling pathway with IC50 of 2.4 uM; shows high efficient cytotoxicity against human leukemic cancer cells HPB-ALL (IC50=7.5 uM) than that of DAPT, decreases the protein levels of HES1 and HES5 in assay cells; accelerates nicastrin degradation, which is one of the components of the γ-secretase complex; also inhibits cell proliferation and induces apoptosis of LoVo cells via the MAPK and Akt signaling pathways.

物理化学性质&存储条件

分子量	478.585
分子式	C29H34O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(2E)-3,7-dimethylocta-2,6-dienyl]-3,6,8-trihydroxy-2-methoxy-7-(3-methylbut-2-enyl)xanthen-9-one

参考文献

1. Arai MA, et al. Sci Rep. 2018 Mar 29;8(1):5376.

2. Chowchaikong N, et al. Int J Oncol. 2018 Apr 3. doi: 10.3892/ijo.2018.4353.

Cowanin (NSC 752810)

生物&药学活性

物理化学性质&存储条件

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Cowanin (NSC 752810)

生物&药学活性

物理化学性质&存储条件

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