欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-新冠病毒相关-SARS-CoV-2 Inhibitors-Coronastat
Coronastat

Chemical Structure : Coronastat

CAS No.: 2922281-15-8

加入收藏

Coronastat (NK01-63)

货号: PC-73341Not For Human Use, Lab Use Only.

Coranastat (NK01-63) is a GC376 analog with improved potency, and highly potent, selective SARS-CoV-2 3CL protease inhibitor with IC50 of 16 nM, exhibits antiviral potency with EC50 of 6 nM in Huh-7ACE2 cellular assays.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Coranastat (NK01-63) is a GC376 analog with improved potency, and highly potent, selective SARS-CoV-2 3CL protease inhibitor with IC50 of 16 nM, exhibits antiviral potency with EC50 of 6 nM in Huh-7ACE2 cellular assays.
NK01-63 exhibited outstanding improvements over GC376 for inhibiting SARS-CoV-2 in vitro and in cells, demonstrated high potency in human Caco-2 cells against SARS-CoV-2 infection with EC90 of 81 nM.
NK01-63 is highly selective for 3CL inhibition, displaying IC50 values of >100 μM against many of the other human proteases and possessing only modest levels of inhibition of caspase 8 (IC50=18 µM), cathepsin B (IC50=1.1 µM), cathepsin K (IC50=0.04 µM), and cathepsin S (IC50=0.03 uM), but with high potency against cathepsin L (IC50=0.006 uM).
NK01-63 exhibits specific pan-coronavirus activities, can effectively block the viral replication of human coronavirus alpha OC43 and human coronavirus beta 229E, with EC50 values < 100 nM in Huh-7 human cells, also blocks replication of MERS-CoV (EC50< 1 µM) and SARS-CoV (EC50< 3 µM) in Vero 76 cells.

物理化学性质&存储条件

分子量 575.532
分子式 C22H29F3N3NaO8S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

sodium (2S)-1-hydroxy-2-((S)-4-methyl-2-((((3-(trifluoromethyl)benzyl)oxy)carbonyl)amino)pentanamido)-3-((S)-2-oxopyrrolidin-3-yl)propane-1-sulfonate

参考文献

1. Hengrui Liu, et al. Nat Commun. 2022 Apr 7;13(1):1891.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: