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首页-小分子抑制剂&激动剂-Apoptosis-Apoptosis Inducer-Corisin
Corisin

Chemical Structure : Corisin

CAS No.: 2651277-02-8

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Corisin

货号: PC-27781Not For Human Use, Lab Use Only.

Corisin is a Staphylococcus pro-apoptotic peptide that induce apoptosis of lung epithelial cells, induces apoptosis of podocytes, keratinocytes, tubular epithelial cells, retinal, and intestinal cells, triggers acute exacerbation of pulmonary fibrosis.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Corisin is a Staphylococcus pro-apoptotic peptide that induce apoptosis of lung epithelial cells, induces apoptosis of podocytes, keratinocytes, tubular epithelial cells, retinal, and intestinal cells, triggers acute exacerbation of pulmonary fibrosis.
Corisin shows no apoptotic activity on lung fibroblast, vascular endothelial cell or lymphocyte cell lines.
Anti-corisin antibody inhibits corisin-induced apoptosis.
Corisin exacerbates lung fibrosis in transforming growth factor β1 transgenic mice.
Corisin synergistically enhances the proapoptotic activity of transforming growth factor-β1 on podocytes.
Corisin interacts with human serum albumin, potentially enhancing its renal accumulation and pathological impact.
Corisin is a microbiota-derived effector that directly couples the collapse of epithelial proteostasis to multimechanistic cell-fate dysregulation and fibrotic remodeling.

物理化学性质&存储条件

分子量 1973.20
分子式 C84H133N25O28S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Ile-Val-Met-Pro-Glu-Ser-Ser-Gly-Asn-Pro-Asn-Ala-Val-Asn-Pro-Ala-Gly-Tyr-Arg

参考文献

1. Yasuma T, et al. Nat Commun. 2025 Aug 25;16(1):7591.

2. D'Alessandro-Gabazza CN, et al. Nat Commun. 2022 Mar 23;13(1):1558.

3. D'Alessandro-Gabazza CN, et al. Nat Commun. 2020 Mar 24;11(1):1539.

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