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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA/RNA Synthesis-Congo red
Congo red

Chemical Structure : Congo red

CAS No.: 573-58-0

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Congo red (Zinc 03830554)

货号: PC-38801Not For Human Use, Lab Use Only.

Congo red (Zinc 03830554) is a high-affinity small molecule targeting mitochondrial DNA polymerase gamma (Pol γ), selectively kills MLH1 deficient cancer cells.

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100 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Congo red (Zinc 03830554) is a high-affinity small molecule targeting mitochondrial DNA polymerase gamma (Pol γ), selectively kills MLH1 deficient cancer cells.
Congo red (Zinc 03830554) binds to the Pol γ protein and potently inhibits Pol γ strand displacement and one-nucleotide incorporation DNA synthesis activities in vitro and in vivo.
Congo red (Zinc 03830554) reduced the cell proliferation of MLH1 deficient HCT116 human colon cancer cells and suppressed HCT116 xenograft tumor growth, did not affect the MLH1 proficient cell proliferation and xenograft tumor growth.
Congo red (Zinc 03830554) caused mitochondrial dysfunction and cell death by inhibiting Pol γ activity and oxidative mtDNA damage repair, increasing the production of reactive oxygen species and oxidative mtDNA damage in MLH1 deficient cells.
Congo red is red in alkaline solution and blue in acid solution and used especially as an indicator and as a biological stain.

物理化学性质&存储条件

分子量 696.664
分子式 C32H22N6Na2O6S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

disodium;4-amino-3-[[4-[4-[(1-amino-4-sulfonatonaphthalen-2-yl)diazenyl]phenyl]phenyl]diazenyl]naphthalene-1-sulfonate

参考文献

1. Berna Somuncu, et al. PLoS One. 2022 Jun 3;17(6):e0268391.

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