Compstatin

Chemical Structure : Compstatin

CAS No.: 206645-99-0

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货号: PC-21941Not For Human Use, Lab Use Only.

Compstatin is a 13-residue cyclic peptide inhibitor of complement C3, specifically binds to C3 and inhibits complement activation by blocking C3 convertase-mediated cleavage of C3.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3880	In stock
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100 mg		Get quote

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生物&药学活性

Compstatin is a 13-residue cyclic peptide inhibitor of complement C3, specifically binds to C3 and inhibits complement activation by blocking C3 convertase-mediated cleavage of C3.
Compstatin effectively inhibits the generation of C3a and sC5b-9 and the binding of C3/ C3 fragments to the polymer surface.
Compstatin prolongs survival of ex vivo perfused pig xenografts.

物理化学性质&存储条件

分子量	1550.78
分子式	C66H99N23O17S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-10,13-Bis((1H-imidazol-4-yl)methyl)-19-((1H-indol-3-yl)methyl)-4-(((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamoyl)-34-((2S,3S)-2-amino-3-methylpentanamido)-25-(3-amino-3-oxopropyl)-7-(3-guanidinopropyl)-28,31-diisopropyl-6,9,12,15,18,21,24,27,30,33-decaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decaazacyclopentatriacontan-22-yl)acetic acid

参考文献

1. Morikis D, et al. Protein Sci. 1998 Mar;7(3):619-27.

2. Nilsson B, et al. Blood. 1998 Sep 1;92(5):1661-7.

3. Fiane AE, et al. Xenotransplantation. 1999 Feb;6(1):52-65.

Compstatin

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