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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cdc2-like Kinase (CLK)-Compound 670551
Compound 670551

Chemical Structure : Compound 670551

CAS No.: 177499-46-6

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Compound 670551

货号: PC-22323Not For Human Use, Lab Use Only.

Compound 670551 is a potent Cdc2-like kinase 2 (CLK2) inhibitor with IC50 of 619.7 nM, inhibits CLK activity by 96% at 10  uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Compound 670551 is a potent Cdc2-like kinase 2 (CLK2) inhibitor with IC50 of 619.7 nM, inhibits CLK2 activity by 96% at 10  uM.
Compound 670551 inhibits TNBC cell growth and survival.
Compound 670551 downregulates serine/arginine‐rich splicing factor (SRSF) phosphorylation and induces cell apoptosis.

物理化学性质&存储条件

分子量 288.35
分子式 C18H16N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9-(1-phenylethyl)-9H-pyrimido[4,5-b]indol-4-amine

参考文献

1. Cheng-Chiao Huang, et al. Protein Sci. 2024 Jun;33(6):e5004.

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