Compound 5104434

Chemical Structure : Compound 5104434

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货号: PC-25164Not For Human Use, Lab Use Only.

Compound 5104434 is a potent, selective activator of HDAC1, selectively activates HDAC1 without significant effects on HDAC2, HDAC3, or HDAC8.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Compound 5104434 is a potent, selective activator of HDAC1, selectively activates HDAC1 without significant effects on HDAC2, HDAC3, or HDAC8.
Compound 5104434 (2.5 uM) partially restored HDAC1 enzymatic activity, while 25 μM fully rescued activity to baseline levels measured via immunoprecipitation-enzyme assays.
Compound 5104434 provides specificity and selectivity in activating HDAC1 in human neural blastoma cell line, SH‐SY5Y.
Compound 5104434 at 30 mg/kg/day i.p. in a rat model of cerebral ischemia significantly restored HDAC1 activity in brain tissues, reduced infarct volume, neuronal apoptosis, DNA damage, and oxidative stress markers.

物理化学性质&存储条件

分子量	292.38
分子式	C17H24O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)methyl)-5,5-dimethylcyclohexane-1,3-dione

参考文献

1. L.-H. Tsai, et al. Activation of Histone Deacetylase 1 (HDAC1) Protects Against DNA Damage and Increases Neuronal Survival (2010), Patent W2010/011318 A2.

2. Costanzo G, et al. Eur J Med Chem. 2025 Jul 23;298:117998.