Compound 3.47 | EBOV inhibitor | Probechem Biochemicals

Chemical Structure : Compound 3.47

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Compound 3.47 (EBOV-IN-1)

货号: PC-23620Not For Human Use, Lab Use Only.

Compound 3.47 is a small molecule antifilovirus compound, inhibits EboV infection by interfering with binding of cleaved virus glycoprotein (GP) to endosomal membrane protein Niemann-Pick C1 (NPC1).

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生物&药学活性

Compound 3.47 (EBOV-IN-1) is a small molecule antifilovirus compound, inhibits EboV infection by interfering with binding of cleaved virus glycoprotein (GP) to endosomal membrane protein Niemann-Pick C1 (NPC1).
Compound 3.47 (EBOV-IN-1) inhibits pseudotyped EBOV infection with an IC50 of 13 nM.
Compound 3.47 (EBOV-IN-1) targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection.

物理化学性质&存储条件

分子量	573.73
分子式	C34H43N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 4-((2-((4-((2-(adamantan-1-yl)acetyl)glycyl)piperazin-1-yl)methyl)phenoxy)methyl)benzoate

参考文献

1. Côté M, et al. Nature. 2011 Aug 24;477(7364):344-8.

Compound 3.47 (EBOV-IN-1)

生物&药学活性

物理化学性质&存储条件

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Compound 3.47 (EBOV-IN-1)

生物&药学活性

物理化学性质&存储条件

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