Compound 2B5

Chemical Structure : Compound 2B5

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货号: PC-20594Not For Human Use, Lab Use Only.

Compound 2B5 is a potent small molecule against S. mutans with IC50 of 1.9 uM, specifically targets the key response regulator VicR (Kd=87 uM) in both S. mutans and S. aureus.

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生物&药学活性

Compound 2B5 is a potent small molecule against S. mutans with IC50 of 1.9 uM, specifically targets the key response regulator VicR (Kd=87 uM) in both S. mutans and S. aureus.
Compound 2B5 exhibits potent antibiofilm activity against S. aureus with IC50 of 3.5 uM.
Compound 2B5 inhibits expression of vicR and VicR-regulated genes, reduces biofilm formation.
Compound 2B5 (100 uM) inhibits S. mutans-induced virulence in a rat model of dental caries, does not significantly affect bacterial colonization.

物理化学性质&存储条件

分子量	392.63
分子式	C23H44N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NCCCCCCCCCCCCCCCC)CCCC1=CNC(N)=N1

参考文献

1. Liu C, et al. mBio. 2023 Apr 19:e0013723.

Compound 2B5

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物理化学性质&存储条件

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Compound 2B5

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