Compound 212-148

Chemical Structure : Compound 212-148

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货号: PC-21419Not For Human Use, Lab Use Only.

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生物&药学活性

Compound 212-148 a bispecific, dual inhibitor of both TMPRSS2 and cysteine proteases cathepsin L/B (CTSL/CTSB) with IC50 of 1.38 uM and 2.13/64.07 nM, respectively, demonstrates antiviral activity against various SARS-CoV-2 variants.
Compound 212-148 simultaneously blocks TMPRSS2- and CTSL/CTSB-mediated viral entry pathways, exhibits synergistic antiviral activity against SARS-CoV-2.
Compound 212-148 inhibits the entry of pseudotyped SARS-CoV-2 Omicron variants BA.2.12.1 and BA.4 & BA.5 with a similar EC50 value of 0.4 nM in Huh-7 cells.
Compound 212-148 inhibits the SARS-CoV-2 Omicron BA.2 and Delta variants infection with EC50 values of 64.4 and 235.2 nM, respectively, in Calu-3 cells.

物理化学性质&存储条件

分子量	765.93
分子式	C41H47N7O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)carbamoyl)piperazin-1-yl)ethyl 4-((diaminomethylene)amino)benzoate

参考文献

1. Haofeng Wang, et al. Nat Commun. 2023 Nov 21;14(1):7574.

Compound 212-148

生物&药学活性

物理化学性质&存储条件

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Compound 212-148

生物&药学活性

物理化学性质&存储条件

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