Compound 14-100 | Hsp70 inhibitor | Probechem Biochemicals

Chemical Structure : Compound 14-100

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Compound 14-100 (Hsp70 inhibitor)

货号: PC-49415Not For Human Use, Lab Use Only.

Compound 14-100 is a small molecule, orally active inhibitor targeting pancreatic cancer cell chemotaxis in vitro and in vivo, inhibits Hsp70 coding genes.

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50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Compound 14-100 is a small molecule, orally active inhibitor targeting pancreatic cancer cell chemotaxis in vitro and in vivo, inhibits Hsp70 coding genes.
Compound 14-100 exhibits potent inhibition of Hsp70 coding genes in pancreatic cancer cells.
Compound 14-100 enhances anti-tumor effect of gemcitabine. increases the expression of KRT14 and KRT16 genes.
Compound 14-100 inhibits metastasis of fluorescence-labeled BxPC-3 cells, which were transplanted into the pancreas of nude mice as a subcutaneously grown cancer fragment.

物理化学性质&存储条件

分子量	331.196
分子式	C17H12Cl2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-chlorophenyl)(5-(4-chlorophenyl)-1-methyl-1H-pyrazol-4-yl)methanone

参考文献

1. Okamoto S, et al. Biomed Pharmacother. 2022 Nov;155:113733.