D5D-IN-326 |CAS:1236767-85-3 Probechem Biochemicals

Chemical Structure : Compound-326

CAS No.: 1236767-85-3

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Compound-326 (D5D inhibitor 326, D5D-IN-326)

货号: PC-63355Not For Human Use, Lab Use Only.

Compound-326 (D5D inhibitor 326, D5D-IN-326) is apotent, selective, orally active delta-5 desaturase (D5D, FADS1/Fatty Acid Desaturase 1) with IC50 of 72 and 22 nM for rat and human D5D, respectively.

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10 mg	￥5480	In stock
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生物&药学活性

Compound-326 (D5D inhibitor 326, D5D-IN-326) is apotent, selective, orally active delta-5 desaturase (D5D, FADS1/Fatty Acid Desaturase 1) with IC50 of 72 and 22 nM for rat and human D5D, respectively.
Compound-326 shows no inhibition for both rat and human D6D and D9D activity.
Compound-326 lowers insulin resistance and caused body weight loss without significant impact on cumulative calorie intake in high-fat diet-induced obese (DIO) mouse model.

物理化学性质&存储条件

分子量	473.279
分子式	C17H11F8N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,2,3,3,3-Pentafluoropropoxy)-3-[4-(2,2,2-trifluoroethoxy) phenyl]-5,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-4,6-dione

参考文献

1. Yashiro H, et al. PLoS One. 2016 Nov 10;11(11):e0166198.

Compound-326 (D5D inhibitor 326, D5D-IN-326)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

Compound-326 (D5D inhibitor 326, D5D-IN-326)

生物&药学活性

物理化学性质&存储条件

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