Columbianadin

Chemical Structure : Columbianadin

CAS No.: 5058-13-9

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货号: PC-28715Not For Human Use, Lab Use Only.

Columbianadin is a coumarin from heracleum brunonis with anti-inflammatory, analgesic, thrombogenesis-inhibiting and anti-tumor effects. inhibits the PI3K/Akt signaling pathway in GBM cells.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

Columbianadin is a coumarin from heracleum brunonis with anti-inflammatory, analgesic, thrombogenesis-inhibiting and anti-tumor effects. inhibits the PI3K/Akt signaling pathway in GBM cells.
Columbianadin inhibits depolarization induced Ca2+ uptake in rat pituitary GH3 cells.
CBN inhibits the growth and proliferation of GBM cells in a dose-dependent manner.
Columbianadin arrested the cell cycle in G0/G1 phase and induced the apoptosis of GBM cells.
Columbianadin inhibited GBM growth in an orthotopic mouse model of GBM through inhibiting PI3K/Akt signaling pathway.
Columbianadin inhibited both mechanical and cold hypersensitivity induced by oxaliplatin.

物理化学性质&存储条件

分子量	328.36
分子式	C19H20O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(2-Oxo-8,9-dihydro-2H-furo[2,3-h]chromen-8-yl)propan-2-yl (Z)-2-methylbut-2-enoate

参考文献

1. Törnquist K, et al. Planta Med. 1990 Feb;56(1):127-9.

2. Zhang W, et al. Biochem Pharmacol. 2024 May;223:116112.

3. Su X, et al. Front Pharmacol. 2020 Jan 9;10:1522.

Columbianadin

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物理化学性质&存储条件

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Columbianadin

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