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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-Colchicine
Colchicine

Chemical Structure : Colchicine

CAS No.: 64-86-8

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Colchicine

货号: PC-27335Not For Human Use, Lab Use Only.

Colchicine is an orally active alkaloid and potent tubulin inhibitor and a microtubule disrupting agent, inhibits microtubule polymerization with IC50 of 3 nM, also is a competitive antagonist of the α3 glycine receptors (GlyRs).

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1 g ￥550 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Colchicine is an orally active alkaloid and potent tubulin inhibitor and a microtubule disrupting agent, inhibits microtubule polymerization with IC50 of 3 nM, also is a competitive antagonist of the α3 glycine receptors (GlyRs).

物理化学性质&存储条件

分子量 399.44
分子式 C22H25NO6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

参考文献

1. Bonfoco E, et al. Exp Cell Res. 1995 May;218(1):189-200.

2. Otani K, et al. Sci Rep. 2016 Sep 2;6:32587.

3. Carola Muñoz-Montesino, et al. Front Pharmacol. 2020 Jul 30;11:1143.

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