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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-Col003
Col003

Chemical Structure : Col003

CAS No.: 328565-16-8

Col003 (Col 003)

货号: PC-62622Not For Human Use, Lab Use Only.

Col003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Col003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47.
Col 003 competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix.

物理化学性质&存储条件

分子量 257.245
分子式 C14H11NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-benzyl-2-hydroxy-3-nitrobenzaldehyde

参考文献

1. Ito S, et al. J Biol Chem. 2017 Dec 8;292(49):20076-20085.

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