Cofilin inhibitor SZ-3 |CAS:2556443-73-1 Probechem Biochemicals

Chemical Structure : Cofilin inhibitor SZ-3

CAS No.: 2556443-73-1

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Cofilin inhibitor SZ-3 (SZ-3)

货号: PC-38009Not For Human Use, Lab Use Only.

Cofilin inhibitor SZ-3 (SZ-3) is a first-in-class small-molecule inhibitor of cofilin, shows potent anti-inflammatory activities.

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5 mg	￥3480	In stock
10 mg	￥5480	In stock
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生物&药学活性

Cofilin inhibitor SZ-3 (SZ-3) is a first-in-class small-molecule inhibitor of cofilin, shows potent anti-inflammatory activities.
SZ-3 shows no effect on neuronal/microglial survival but prevents microglia from LPS-induced inflammation by decreasing NO and preventing neurotoxicity.
SZ-3 decreases cofilin severing activity, and attenuates microglial activation and suppresses migration and proliferation in LPS-activated HMC-3 cells.
SZ-3 shows significantly decreased NO and TNF-α, significantly increases protein expression of phosphocofilin, and decreases PAR-1 in model for hemorrhagic stroke.
SZ-3-treated SHSY-5Y showed a significant increase in cell viability by significantly reducing nuclear factor-κ B (NF-κB), caspase-3, and high-temperature requirement (HtrA2).

物理化学性质&存储条件

分子量	481.681
分子式	C29H43N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(bis(5-(tert-butyl)-2-hydroxybenzyl)amino)cyclohexyl)urea

参考文献

1. Alaqel SI, et al. ACS Chem Neurosci. 2022 Apr 6;13(7):1014-1029.

Cofilin inhibitor SZ-3 (SZ-3)

生物&药学活性

物理化学性质&存储条件

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Cofilin inhibitor SZ-3 (SZ-3)

生物&药学活性

物理化学性质&存储条件

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