Cobimetinib (GDC-0973, XL518) | MEK inhibitor | Probechem Biochemicals

Chemical Structure : Cobimetinib

CAS No.: 934660-93-2

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Cobimetinib (GDC-0973, XL518, GDC0973, XL-518)

货号: PC-43369Not For Human Use, Lab Use Only.

Cobimetinib (GDC-0973, XL518) is a potent, selective MEK inhibitor with IC50 of 4.2 nM for MEK1.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg	￥4280	In stock
250 mg		Get quote

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生物&药学活性

Cobimetinib (GDC-0973, XL518) is a potent, selective MEK inhibitor with IC50 of 4.2 nM for MEK1.
Cobimetinib (GDC-0973, XL518) shows excellent selectivity against mTOR, DNA-dependent protein kinase (DNA-PK), and a panel of more than 228 kinases.
Cobimetinib (GDC-0973, XL518) shows strong cellular potency in a broad panel of tumor types, particularly in BRAF or KRAS mutant cancer cell lines, triggers robust apoptosis and tumor growth inhibition in vivo combined with PI3K inhibitor GDC-0941.

物理化学性质&存储条件

分子量	531.31
分子式	C21H21F3IN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanone, [3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl]-

参考文献

1. Hoeflich KP, et al. Cancer Res. 2012 Jan 1;72(1):210-9.

2. Wong H, et al. Clin Cancer Res. 2012 Jun 1;18(11):3090-9.

3. Rice KD, et al. ACS Med Chem Lett. 2012 Apr 9;3(5):416-21.

4. Ribas A, et al. Lancet Oncol. 2014 Aug;15(9):954-65.

Cobimetinib (GDC-0973, XL518, GDC0973, XL-518)

生物&药学活性

物理化学性质&存储条件

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Cobimetinib (GDC-0973, XL518, GDC0973, XL-518)

生物&药学活性

物理化学性质&存储条件

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