Cobicistat (GS-9350) | CYP3A inhibitor | Probechem Biochemicals

Chemical Structure : Cobicistat

CAS No.: 1004316-88-4

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Cobicistat (GS-9350, GS9350)

货号: PC-42617Not For Human Use, Lab Use Only.

Cobicistat (GS-9350) is a pharmacoenhancer that acts as potent and selective inhibitor of human CYP3A with IC50 of 30-285 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2280	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

Cobicistat (GS-9350) is a pharmacoenhancer that acts as potent and selective inhibitor of human CYP3A with IC50 of 30-285 nM.
Cobicistat (GS-9350) is a more selective than RTV with much reduced inhibitory activity toward CYP2D6, CYP2C8, and CYP2C9.

物理化学性质&存储条件

分子量	776.0227
分子式	C40H53N7O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	2,7,10,12-Tetraazatridecanoic acid, 12-methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3R,6R,9S)-

参考文献

1. Xu L, et al. ACS Med Chem Lett. 2010 May 17;1(5):209-13.

2. Lepist EI, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5409-13.

3. Stray KM, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4982-9.

Cobicistat (GS-9350, GS9350)

生物&药学活性

物理化学性质&存储条件

参考文献

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Cobicistat (GS-9350, GS9350)

生物&药学活性

物理化学性质&存储条件

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