Cobalt protoporphyrin IX (CoPPIX) is a potent and effective inducer of HO-1 (heme oxygenase-1) activity, up-regulates HO-1 via Bach1 and Nrf2 in human liver cells.
Cobalt protoporphyrin IX (CoPPIX) is a potent and effective inducer of HO-1 (heme oxygenase-1) activity, up-regulates HO-1 via Bach1 and Nrf2 in human liver cells.
CoPPIX did not influence hepatic Bach1 or Nrf2 mRNA levels, but markedly reduced Bach1 protein levels by increasing degradation of Bach1 protein, and increased Nrf2 by decreasing degradation of Nrf2 protein.
CoPPIX significantly upregulated HO-1 protein in mucosal and submucosal cells.
CoPPIX is a direct Bach1 inhibitor.
