ClpXP inhibitor 334

Chemical Structure : ClpXP inhibitor 334

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货号: PC-72076Not For Human Use, Lab Use Only.

ClpXP inhibitor 334 is a small molecule inhibitor of the mitochondrial ClpXP protease with anti-cancer activity.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

ClpXP inhibitor 334 is a small molecule inhibitor of the mitochondrial ClpXP protease with anti-cancer activity.
ClpXP inhibitor 334 impaired viability and colony formation of various leukemia cell lines efficiently reduced the viability of Jurkat cells with IC50 of 12.93 uM.
ClpXP inhibitor 334 induced cell death in ALL and AML PDX cells and PBMCs by impairing the integrity of the mitochondrial membrane potential (MMP), induced cellular stress and alters the mitochondrial proteostasis.
ClpXP inhibitor 334 enhanced chemo-sensitivity of leukemia cells towards chemotherapy.

物理化学性质&存储条件

分子量	357.427
分子式	C22H15NO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	11-(3-hydroxyphenyl)-5,11-dihydro-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-one

参考文献

1. Martina Meßner, et al. Sci Rep. 2021 May 27;11(1):11185.