ClpP agonist TR-65 | ClpP agonist | Probechem Biochemicals

Chemical Structure : ClpP agonist TR-65

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ClpP agonist TR-65 (TR65)

货号: PC-49803Not For Human Use, Lab Use Only.

ClpP agonist TR-65 is a potent small molecule agonist of mitochondrial ClpP protease with KD value of 23.3 nM.

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生物&药学活性

ClpP agonist TR-65 is a potent small molecule agonist of mitochondrial ClpP protease with KD value of 23.3 nM.
TR-57 exhibits the growth inhibition with a ClpP-dependent manner in both MDA-MB-231 and HEK293 T-REx cells with IC50 of 9.4 and 9.8 nM, respectively.
TR-27 induces ClpP-dependent proteolysis on the N-terminome of the proteome in MDA-MB-231 cells.

物理化学性质&存储条件

分子量	431.92
分子式	C24H22ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-(4-chlorobenzyl)-5-oxo-1,2,4,5,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-7(6H)-yl)methyl)benzonitrile

参考文献

1. Mark F Mabanglo, et al. Structure. 2023 Feb 2;31(2):185-200.e10.

ClpP agonist TR-65 (TR65)

生物&药学活性

物理化学性质&存储条件

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ClpP agonist TR-65 (TR65)

生物&药学活性

物理化学性质&存储条件

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