ClpP agonist TR-27 | ClpP agonist | Probechem Biochemicals

Chemical Structure : ClpP agonist TR-27

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ClpP agonist TR-27 (TR27)

货号: PC-49801Not For Human Use, Lab Use Only.

ClpP agonist TR-27 is a potent small molecule agonist of mitochondrial ClpP protease with KD value of 23.7 nM.

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生物&药学活性

ClpP agonist TR-27 is a potent small molecule agonist of mitochondrial ClpP protease with KD value of 23.7 nM.
TR-27 exhibits the growth inhibition with a ClpP-dependent manner in both MDA-MB-231 and HEK293 T-REx cells with IC50 of 90.7 and 46.1 nM, respectively.
TR-27 exhibits 20-fold improvement in growth inhibition over the parent molecule ONC201.
TR-27 induces ClpP-dependent proteolysis on the N-terminome of the proteome in MDA-MB-231 cells.

物理化学性质&存储条件

分子量	430.94
分子式	C25H23ClN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-chlorobenzyl)-7-(3-ethynylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one

参考文献

1. Mark F Mabanglo, et al. Structure. 2023 Feb 2;31(2):185-200.e10.

ClpP agonist TR-27 (TR27)

生物&药学活性

物理化学性质&存储条件

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ClpP agonist TR-27 (TR27)

生物&药学活性

物理化学性质&存储条件

参考文献

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