Clovibactin

Chemical Structure : Clovibactin

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货号: PC-21050Not For Human Use, Lab Use Only.

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1 g		Get quote

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生物&药学活性

Clovibactin is a novel depsipeptide antibiotic, exhibits antibacterial activity against a broad range of Gram-positive pathogens (MIC, 1-2 ug/mL, ATCC 33591 MRSA), Clovibactin targets cell wall biosynthesis.
Clovibactin exhibits antibacterial activity against a broad range of Gram-positive pathogens, including MRSA, daptomycin-resistant and vancomycin-intermediate-resistant S. aureus (VISA) strains, and difficult to treat vancomycin-resistant Enterococcus faecalis20 and E. faecium (vancomycin-resistant enterococci [VRE]).
Clovibactin is more effective in killing S. aureus compared with vancomycin, the first line of defense antibiotic.
Clovibactin does not show any cytotoxicity against mammalian NIH/3T3 and HepG2 cells at 100 μg/mL.
Clovibactin is efficacious in a mouse model of S. aureus infection.
Clovibactin uses an unusual hydrophobic interface to target immutable pyrophosphate.

物理化学性质&存储条件

分子量	903.09
分子式	C43H70N10O11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,6S,9S,12R,13R)-12-((S)-2-((R)-6-amino-2-((R)-2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanamido)hexanamido)-3-hydroxypropanamido)-3,6-diisobutyl-9-methyl-2,5,8,11-tetraoxo-1-oxa-4,7,10-triazacyclotridecane-13-carboxamide

参考文献

1. Shukla R, et al. Cell. 2023 Aug 16:S0092-8674(23)00853-X.

Clovibactin

生物&药学活性

物理化学性质&存储条件

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Clovibactin

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