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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Nucleoside Antimetabolite/Analog-Clitocine
Clitocine

Chemical Structure : Clitocine

CAS No.: 105798-74-1

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Clitocine

货号: PC-60461Not For Human Use, Lab Use Only.

A naturally occurring nucleoside analog that possesses antitumor activity, also is a potent and efficacious readthrough agent.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A naturally occurring nucleoside analog that possesses antitumor activity, also is a potent and efficacious readthrough agent; weakly inhibits adenosine kinase (Ki=3 uM), and inhibits L1210 cells in vitro with LD50 of 30 nM; potently inhibits Mcl-1, effectively induces drug-resistant human cancer cell apoptosis in vitro and inhibits tumor xenograft growth in vivo; a potent and efficacious suppressor of nonsense mutations.

物理化学性质&存储条件

分子量 287.232
分子式 C9H13N5O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-Amino-5-nitro-4-(ribofuranosylamino)pyrimidine

参考文献

1. Moss RJ, et al. J Med Chem. 1988 Apr;31(4):786-90.

2. Lee CH, et al. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2419-22.

3. Sun JG, et al. Apoptosis. 2014 May;19(5):871-82.

4. Friesen WJ, et al. RNA. 2017 Apr;23(4):567-577.

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