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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Immune Checkpoints-CliMB-325
CliMB-325

Chemical Structure : CliMB-325

CAS No.:

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CliMB-325 (Click MHC-I Booster-325, CliMB325)

货号: PC-25773Not For Human Use, Lab Use Only.

CliMB-325 is a small molecule modulator/ inducer of MHC‑I surface expression, induces MHC-I surface expression levels in CT26 cells with EC50 of 498 nM, also enhances T cell activation and exhibits lower toxicity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CliMB-325 is a small molecule modulator/ inducer of MHC‑I surface expression, induces MHC-I surface expression levels in CT26 cells with EC50 of 498 nM, also enhances T cell activation and exhibits lower toxicity.

物理化学性质&存储条件

分子量 386.20
分子式 C15H9Cl2N9
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-((2-amino-6-chloro-9H-purin-9-yl)methyl)-1H-1,2,3-triazol-1-yl)-5-chlorobenzonitrile

参考文献

1. Newkirk SE, et al. J Med Chem. 2025 Nov 13;68(21):22301-22311.

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