Clemizole |CAS:442-52-4 Probechem Biochemicals

Chemical Structure : Clemizole

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Clemizole

货号: PC-45789Not For Human Use, Lab Use Only.

An H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.

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生物&药学活性

Clemizole is an H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.
Clemizole also selectively and efficiently blocks TRPC5 currents and Ca(2+) entry with IC50 of 1-1.3 uM, 6-fold selectivity over TRPC4β (IC50 = 6.4 µM), and almost 10-fold selectivity over TRPC3 (IC50 =9.1 uM) and TRPC6 (IC50=11.3 uM), only very weakly affects TRPM3, TRPM8 and TRPV1, V2, V3, and V4 channels.

物理化学性质&存储条件

分子量	325.8352
分子式	C19H20ClN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-

参考文献

1. Richter JM, et al. Mol Pharmacol. 2014 Nov;86(5):514-21.

2. Einav S, et al. Nat Biotechnol. 2008 Sep;26(9):1019-27.

3. Einav S, et al. J Infect Dis. 2010 Jul 1;202(1):65-74.

Clemizole

生物&药学活性

物理化学性质&存储条件

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Clemizole

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物理化学性质&存储条件

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