Chemical Structure : Clazakizumab
CAS No.: 1236278-28-6
货号: PC-Ab1084Not For Human Use, Lab Use Only.
Clazakizumab (ALD518, BMS 945429) a humanized anti–IL-6 mAb, targets human IL-6 with an affinity of 4 pM, binds circulating IL-6 cytokine rather than the IL-6 receptor 10, 11, blocking both classic signaling and trans-signaling. significantly improves disease activity in rheumatoid arthritis (RA). It has also been evaluated for the treatment of non-small cell lung cancer (NSCLC) and patients with head and neck cancer..
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Clazakizumab (ALD518, BMS 945429) a humanized anti–IL-6 mAb, targets human IL-6 with an affinity of 4 pM, binds circulating IL-6 cytokine rather than the IL-6 receptor 10, 11, blocking both classic signaling and trans-signaling. significantly improves disease activity in rheumatoid arthritis (RA). It has also been evaluated for the treatment of non-small cell lung cancer (NSCLC) and patients with head and neck cancer.
分子量 | ||
分子式 | Human IgG1-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Clazakizumab; ALD518; BMS 945429;1236278-28-6; Anti-human IL-6; anti-human Interleukin 6 |
1. 1, Bayliss TJ, et al. Expert Opin Biol Ther. 2011 Dec;11(12):1663-8. 2, Karkhur S, et al. J Ophthalmic Inflamm Infect. 2019 Sep 16;9(1):17. 3, Weinblatt ME, et al. Arthritis Rheumatol. 2015 Oct;67(10):2591-600. 4, Mühlbacher J, et al. Transpl Int. 2021 Aug;34(8):1542-1552.
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