Claudin 5 binder CL5B | CLDN5 binder | Probechem Biochemicals

Chemical Structure : Claudin 5 binder CL5B

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Claudin 5 binder CL5B (CLDN5 binder)

货号: PC-25817Not For Human Use, Lab Use Only.

Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery.
CL5B enhances endothelial permeability and promotes small-molecule permeation.
CL5B reversibly enhances endothelial permeability by altering CLDN5 localization.
CL5B regulates mouse BBB and promotes drug delivery to the brain.
CL5B-mediated methylscopolamine delivery to the brain alleviates epilepsy in an experimental mouse model.

物理化学性质&存储条件

分子量	269.34
分子式	C17H19NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(4-isopropylphenyl)-3-(5-methylfuran-2-yl)acrylamide

参考文献

1. Inoue S, et al. J Control Release. 2025 Oct 11:114314.