Claficapavir (A1752)

Chemical Structure : Claficapavir

CAS No.: 2055732-24-4

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货号: PC-73411Not For Human Use, Lab Use Only.

Claficapavir (A1752) is a specific small molecule inhibitor of HIV-1 nucleocapsid protein (Kd=20 nM), shows a strong antiviral efficacy with IC50 of 1 uM.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Claficapavir (A1752) is a specific small molecule inhibitor of HIV-1 nucleocapsid protein (Kd=20 nM), shows a strong antiviral efficacy with IC50 of 1 uM.
A1752 binds directly to HIV-1 nucleocapsid protein (NC), specificly inhibits the chaperone functions of NC including Psi RNA dimerization and complementary trans-activation response element (cTAR) DNA destabilization.
A1752 also disrupts the proper Gag processing.
A1752 generates noninfectious viral particles with defects in uncoating and reverse transcription in the infected cells.

物理化学性质&存储条件

分子量	393.856
分子式	C17H12ClNO4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid

参考文献

1. Kim MJ, et al. Retrovirology. 2015 Nov 6;12:90.

2. Suppiah J, et al. Hepat Mon. 2014 Nov 30;14(12):e22565.