Cladoniamide A

Chemical Structure : Cladoniamide A

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货号: PC-27037Not For Human Use, Lab Use Only.

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生物&药学活性

Cladoniamide A is a reversible broad-spectrum antiviral targets the human V-ATPase VO domain, interferes with V-ATPase-dependent acidification of the host endolysosomal network thus preventing viral entry.
Cladoniamide A shows single-digit nanomolar antiviral activity and a high selectivity index (SI: 10 3 -10 4 ) against human enveloped viruses [e.g., SARS-CoV-2 variants, influenza A viruses (H1N1, H5N1), respiratory syncytial virus, dengue serotypes 1-4, and Zika virus].
Cladoniamide A inhibits the V-ATPase rotary motor by occupying unique binding sites in the membrane-embedded V o motor.

物理化学性质&存储条件

分子量	437.84
分子式	C22H16ClN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(5aR,8aS)-10-chloro-5a,8a-dihydroxy-14-methoxy-7-methyl-8a,13-dihydropyrrolo[3',4':5,6]pyrido[1,2-a:3,4-b']diindole-6,8(5aH,7H)-dione

参考文献

1. Pérez-Vargas J, et al. Res Sq [Preprint]. 2026 Jun 3:rs.3.rs-9889115.

Cladoniamide A

生物&药学活性

物理化学性质&存储条件

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Cladoniamide A

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物理化学性质&存储条件

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