ClGBI

Chemical Structure : ClGBI

CAS No.: 70590-32-8

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货号: PC-23858Not For Human Use, Lab Use Only.

ClGBI is a selective blocker/inhibitor of voltage-gated proton channel Hv1 (HVCN1) with Kd of 26 uM, induces acidification of leukemic Jurkat T cells promoting cell death by apoptosis.

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5 mg	￥1480	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
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生物&药学活性

ClGBI is a selective blocker/inhibitor of voltage-gated proton channel Hv1 (HVCN1) with Kd of 26 uM, induces acidification of leukemic Jurkat T cells promoting cell death by apoptosis.
ClGBI directly on hKV1.3 using a whole-cell patch clamp and found an inhibitory effect similar in magnitude to that seen on hHV1 (Kd ≈ 72 μM).
ClGBI inhibits hKV1.1, hKV1.4-IR, hKV1.5, hKV10.1, hKV11.1, hKCa3.1, hNaV1.4, and hNaV1.5 channels with Kd of 12-894 uM.

物理化学性质&存储条件

分子量	209.64
分子式	C8H8ClN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-chloro-1H-benzo[d]imidazol-2-yl)guanidine

参考文献

1. Asuaje A, et al. Pflugers Arch. 2017 Feb;469(2):251-261.

2. Gattas MV, et al. Redox Biol. 2020 Jan;28:101346.

3. Szanto TG, et al. Pharmaceuticals (Basel). 2023 Apr 27;16(5):656.

ClGBI

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物理化学性质&存储条件

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ClGBI

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