Cl-OCH3 | NR4A1 antagonist | Probechem Biochemicals

Chemical Structure : Cl-OCH3

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Cl-OCH3 (NR4A1 inhibitor Cl-OCH3)

货号: PC-38223Not For Human Use, Lab Use Only.

Cl-OCH3 is an antagonist of nuclear receptor NR4A1, decreases PD-L1 protein expression in MDA-MB-231 and 4T1 cells with EC50 of 4.4 and 4.1 uM, respectively.

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生物&药学活性

Cl-OCH3 is an antagonist of nuclear receptor NR4A1, decreases PD-L1 protein expression in MDA-MB-231 and 4T1 cells with EC50 of 4.4 and 4.1 uM, respectively.
Cl-OCH3 decreased expression of PD-L1 mRNA, promoter-dependent luciferase activity, and protein. In in vivo studies using a syngeneic mouse model bearing orthotopically injected 4T1 cells.
Cl-OCH3 decreased tumor growth and weight and inhibited lung metastasis.
Cl-OCH3 also decreased expression of CD3+/CD4+/CD25+/FoxP3+ regulatory T cells and increased the Teff/Treg ratio.

物理化学性质&存储条件

分子量	402.878
分子式	C24H19ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1-bis(3'-indolyl)-1-(3-chloro-4-hydroxy-5-methoxyphenyl)methane

参考文献

1. Keshav Karki, et al. Cancer Res. 2020 Mar 1;80(5):1011-1023.

Cl-OCH3 (NR4A1 inhibitor Cl-OCH3)

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物理化学性质&存储条件

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Cl-OCH3 (NR4A1 inhibitor Cl-OCH3)

生物&药学活性

物理化学性质&存储条件

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